Large-vessel correlates of cerebral small-vessel disease

Population Imaging of Cerebral Small Vessel Disease

Background – We previously reported on the high prevalence of cerebral micro bleeds (CMBs) in community-dwelling people aged 60 years and older. Moreover, we found that their spatial distribution likely reflects differences in underlying etiology. We have since almost quadrupled the number of participants in our study and expanded it to include persons of 45 years and older. We examined the pre...

Advanced Neuroimaging of Cerebral Small Vessel Disease

OPINION STATEMENT Cerebral small vessel disease (SVD) is characterised by damage to deep grey and white matter structures of the brain and is responsible for a diverse range of clinical problems that include stroke and dementia. In this review, we describe advances in neuroimaging published since January 2015, mainly with magnetic resonance imaging (MRI), that, in general, are improving quantif...

Multimodal MRI of Cerebral Small Vessel Disease

Genetics of Cerebral Small Vessel Disease

Cerebral small vessel disease (SVD) is an important cause of stroke and cognitive impairment among the elderly and is a more frequent cause of stroke in Asia than in the US or Europe. Although traditional risk factors such as hypertension or diabetes mellitus are important in the development of cerebral SVD, the exact pathogenesis is still uncertain. Both, twin and family history studies sugges...

Hypercholesterolemia induced cerebral small vessel disease

BACKGROUND While hypercholesterolemia plays a causative role for the development of ischemic stroke in large vessels, its significance for cerebral small vessel disease (CSVD) remains unclear. We thus aimed to understand the detailed relationship between hypercholesterolemia and CSVD using the well described Ldlr-/- mouse model. METHODS We used Ldlr-/- mice (n = 16) and wild-type (WT) mice (n...